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Seeing that you have been having attack for past 10 years I would say 200mg dosage of AlloP is too low. It took me 300mg of AlloP for close to 6 months before I finally seem to be getting control of my Gout. The whole Gout attack thing started for me only 1 year ago so in your case I think it will take longer as you possibly have lot more uric acid crystal build up than me. Which is kind of confirmed by the fact that unlike me you have attacks in your knees, wrists….I assume toes too…..
So yes keep with the AlloP and increase the dosage to atleast 300mg. Also you don't mention anything about your SUA readings? Gout = controlling SUA levels and that is what AlloP at correct dosage is for. SUA numbers is directly proportional to your AlloP dosage. Wrong dosage means you are wasting your time.
Utubelite said:
I used to get cold feet when I started Allop treatment but after few weeks, the cold feet sensations went away.
I never felt hot feet within 10 minutes of wearing the shoes though I do get the hot sensations in the heels when I wear the shoes for long time, and I mean 10 hrs plus by long time.
I generally wear shoes around 9 am and keep them on till 9 pm or so.
Sorry mate I should have been clearer. My feet have always been cold as far back as I can remember. So in my case AlloP has nothing to do with it. I just meant that cold feet increase the chance of crystals formation even when the SUA is in the under 6….6.8mg/dl level ie. safe level. So imagine if normally crystal formed at say exactly 6.8mg/dl level for me then because of cold feet it could form at 5.5 mg/dl level. That was just an illustrative example as I don't know how much imapct it must be having on crystal soluability or formation.
Not sure as it does not resemble my Gout. In fact I was going to start a thread about cold feet. My feet stay cold even when I wear woollen socks!
I got my blood tests done recently as my father has Gout + Type II Diabetes.
My fasting readings were-
Glucose 3.7 (3.9-6.1)
HbA1c 5.6% (4.8-6.0)
Should I worry about my A1c numbers?
Am I walking toward Diabetes too? 
Richard Bell said:
(There is definitely an anti Uloric mind set on this forum but “gouty’s” have good reason to be a little cynical over anything coming from the medical/pharm industry that basically ignored our plight for so many years.)
For me it's a simple case of taking the best and most proven Gout med out there. That in my humble opinion seems to be AlloP. Uloric is too new for me to trust. Once all the guinea pigs have tested it for many years and if it proves to be superior to AlloP then I will switch in a heart beat, until that time AlloP goes with me to my grave
Hopefully we will get new drugs in the future that are 100 times superior to AlloP and Uloric.
Nate hang in there. Have you been X-rayed for all the joints that have pain? What is the joint/bone spacing like in those X-rays? What about the bone surface? Rough and jagged or smooth?
My joint spacing is very good and still I suffered so much for one year. If your joints are more damaged then I can't even imagine the pain you must be going through.
Anyway Gout brotherhood is always here to listen to you
I updated my signature Tony 🙂 BBB did absolutely nothing for me neither did cherry. The onyl thing that worked for me was AlloP
Yes it could be Gout although looks can be deceiving so get your blood SUA readings when the attack is gone. Readings during an attack are lower generally so not very accurate.
Oh! and put some cream on your foot for the dryness
Nate hang in there! I seem to be coming out of my nightmare (fingres crossed) so I truly hope your nightmare ends soon too.
monaco said:
A gout study specialist has told me that AlloP has about 20-30% chance of working and Uloric is 70-80%.
AlloP seems to be working 100% for me. On what basis does he say ONLY 20-30% chance of working? If it lowers your SUA is that not working enough for him?
Welcome to Gout land
I was in the same boat as you. I am relatively young too (mid 30s) and a new Gouty. Btw I have been vegetarian for 10 years even then I ended up with Gout this year.My advice to you is –
a) Get joint fluid test to get proper confirmation of Gout.
b) Your Gout is hereditary like mine so diet won't make much difference.
c) If Gout is confirmed then go on AlloP and ignore the nay sayers. There are a small minority who react badly to AlloP but majority don't. First few months on AlloP made me tired but eventually my body adjusted to it.
d) AlloP will or could cause attacks initially as part of the clean up process. Stick with it.
e) AlloP 300mg with good vegetarian diet is what I personally do.
zip2play said:
Post edited 6:46 pm – May 28, 2010 by zip2play
So you are buying the old patented ZYLOPRIM. (Can I ask WHY?)
I buy generic allopurinol and get it at any major big store pharmacy in the U.S. for $40 a year without using my insurance. ($10 for a 90 day supply of 300 mg.)
My bad as I confused my first 30 tablet pack with my current 100 tablet pack price.
So it is actually $30 for a pack of 100 tablets. So $109 for the year instead of the $360 that I mentioned previously. Not as cheap as US though
Well the doc gives the prescription and the pharmacy supplies the med. The pack does not mention ZYLOPRIM any where.Wiki says-
Sandoz is the generic drug subsidiary of Novartis, a multinational pharmaceutical company. The company develops, manufactures and markets off-patent medicines as well as pharmaceutical and biotechnological active ingredients.
odo said:
VegG, you needn't be too concerned about gout causing serious kidney damage, as it is almost always the other way round and the result of other more serious conditions e.g diabetes, malignant hypertension, leukaemia, and the drugs used to combat them: chemo, thiazides etc. This is considered to occur 'very rarely' – usually from obstruction by urate crystals in the ureters or renal tubules and can usually be flushed out using a catheter (bit like unblocking the sink).
So, relax because if you were in any danger of renal failure you would already know about it and gout would be the least of your worries. As Zip says, all will be revealed by the blood tests.
Thanks Odo. I am worried mainly because my dad who is in his late 70s has Type II diabetes and Gout (for most of his life his diet was not good).
I had such a good and healthy diet and am only in my 30s but already have Gout so I wonder and fear that maybe diabetes is coming next?
cjeezy said:
Post edited 8:08 pm – May 25, 2010 by cjeezy
Your post is interesting, and maybe someone with a little medical background can chime in as I just got back from a chiropractic presentation today and they claimed that organ damage cannot be detected until it has been at least 60% damaged. Any truth to this?
Wiki mentions 60% too…..
Don't understand the text clearly but here it is-
en.wikipedia.org/wiki/Renal_function
Unfortunately, blood urea nitrogen (BUN) and creatinine will not be raised above the normal range until 60% of total kidney function is lost. Hence, the more accurate Glomerular filtration rate or its approximation of the creatinine clearance are measured whenever renal disease is suspected or careful dosing of nephrotoxic drugs is required.
hansinnm said:
vegetarianGuy said:
…ME, ich spreche sehr schlecht Deutsch
VG, you got an excellent translator.
Yes my wife
Seriously though I speak basic German. I wrote that myself but was not sure about spelling so used Google translate as wife was not nearby Nate I was reading your blog and please correct me if I read wrong but do you have only one kidney? If yes then could that be making things lot worse with regards to processing the uric acid? I understand that you are testing your kidney regularly and it is working normal but I wonder if it's working overtime, 600mg AlloP must be taxing for your body too.
Did your Gout start when you went down to 1 kidney?
ME, ich spreche sehr schlecht Deutsch
ME said:
I have had two instances where my left knee has blown up like a watermelon. First instance was 2007 when I had 600 cc of fluid drained ! Swollen half way up my thigh. Not pretty and the nerve pain was just wonderful ;- The fluid was clear upon removal so the orthopedic didn't think there was a problem ;-( Second drain was opaque or milky and tests revealed no gout crystals. I have a regular foot doctor that I go to only because I have had my left achilles operated in 2004. He is the doc I saw when I self diagnosed gout after the crab eating contest. Right big toe, which I will report is now going south fast and I am none to happy right now!! He has taken blood from last three attacks. I don't like taking any of the gout meds, don't like them indeed so refuse to take the meds and meds for Reiters are worse! I will just have to deal with it because I can't get a shoe on and wont be able to drive to the docs! Anyone got a hatchet?
So if the tests revealed no Gout related crystals then on what basis are you saying that you have Gout? Also if you really have Gout then how will you prevent future problems if not by going on AlloP or similar drugs? Also you need to work out what your non attack period SUA readings are!
hansinnm said:
No, VG. I never had any kind of diabetis. I had tophi on both feet and both hands over the past 10 years.
Ok thanks for clearing that. Just wanted to be clear in case that had anything to do with Diabetic foot ulcers.
So you are in your 80s? Those injuries must hurt a lot? Can anything be done to fix it? What are the Docs saying now?
I don't take any Colchine or Alpurinol or any meds. I find when under an attack nothing but a steroid injection helps
Why won't you take AlloP? AlloP is not for pain anyway. It's for treating the underlying cause of your Gout ie. Hyperuricemia. Your steroid injection won't treat the cause.
Your SUA readings during a Gout attrack are meaningless as they are not real indicator of non attack readings.
Never been a big beef eater, mostly chicken
Chicken is no good either for Gout.
Hang in there. I guess no words from me will make the pain bearable.
After seven months of 600mg/day of Allopurinol, is this supposed to be happening?
Probably yes with the amount of build up you must have. I am actually thinking about the same question. 3+ months on it and attacks definitely have got weaker and I feel I just had my last AlloP induced 5th attack (time will tell) but I have constant discolaration in my toe area and slight inflamation with accompanying constant low level pain.
Nothing compared to your pain though. Still I think it will take time. Personally in my case I think I will start panicking after 12months.
Two quotes –
……it takes a few weeks or months for it to start working. Also, allopurinol can initially cause gout attacks.
….Also make sure your doctor has given you medications to prevent attacks during the first 6-12 months of treatment.
zip2play said:
It's just a matter of time before everyone with gout will start to take the meds. Gouties are divided into two groups:
1. those taking allopurinol, uloric or probenecid,
2. those who have not yet started their eventual meds.
Wise words!
THANKS for posting those images Hansinnm. Really APPRECIATE IT! My heart hurt looking at those images.
I hope some of the people here who take Gout lightly and don't manage it will take notice. The amount of ignorance and head in the sand behaviour I find online and in real world is amazing.
Hansinnm are those foot photos Tophy/Gout induced only or do you have Diabetes too?
Trev I hope you are feeling bit better now? I agree with what Odo said.
Also because I care about you I would say that you seem to be taking your 7.4mg/dl SUA reading too lightly
You know that you need to bring it down!Sorry if I don't remember but do you have any blood sugar issues?
In contrast, in series 2, prolonged sub-maximal exercise failed to stimulate increases in uric acid concentration either between days or within days.
Zip now I need to work out what my sub-maximal exercise levels are? How the hell do I do that?
Some examples-
Ex.1 – 30 pull ups in one go with 5 minutes pause followed by 50 push ups per day. Would that be sub-maximal ie. safe?
Ex.2 – Weight training 30 minutes 4 times a week but reducing my weights by 30% or so but upping the reps?
Ex.3- Biking 50 kms at gentle pace?
Looks like I just will have to take the SUA testing kit with me to gym and check different exercise combinations to see what keeps my SUA stable and below sub-maximal.
Jeez! people go gym to work out and I will be goign to not work out too much LOL Oh! the joke nature is playing on me.
EDIT- As there is no device that does real time SUA measuring while exercising would heart rate monitor be a good general idicator for not going overboard? Although weight training does not raise heart rate too much but still can be very damaging from Gout angle. Hmm don't know what are safe exercise levels anymore.
Differential effects of exercise intensity on serum uric acid concentration.
Green HJ, Fraser IG.
Department of Kinesiology, University of Waterloo, Ontario, Canada.
……………..It is concluded that exercise intensity rather than total work output is a critical factor mediating increases in blood uric acid concentration. These results are consistent with the interpretation that uric acid formation may arise from purine nucleotide degradation and fast-twitch fiber utilization during conditions of high energy utilization.
PMID: 3343917 [PubMed – indexed for MEDLINE]
monaco said:
This is interesting, I've actually heard from my doctor that her patients whom she prescribed allopurinol to actually had to come back because of attacks. Perhaps they eat a lot of food from the 'don't even touch list'.
Maybe we can research to see what allopurinol actually originated from and eat from that natural source? have you considered that veggieguy?
AlloP causes more attacks initially. That is normal known and fully understood part of the treatment. Let me give you a crude example. Say you have a shirt covered in shit. It will stink right? You then shrink wrap it in plastic. Now the shit does not smell bad as it is covered and sealed for now. What AlloP does is equivalent of opening the shrink wrap again and washing the shit away
So yes when you initially re-open the package it will stink up the place ie. more Gout attacks initially but once shirt has been been washed clean then Gout would have been tamed.So AlloP = washing powder/ washing machine
All your Eastern remedies = staring at the stinky shirt hoping the stare would clean it
AlloP probably originated in the lab. If a natural cure really works then it gets clinically tested and becomes part of Medical science. Everything else like Tiger's private parts for example are just folklore and bull crap.
If you are on AlloP and continue eating trigger foods like organ meat and stuff. Drink lot of beer etc then yes problems will occur as you are adding more shit into the mix and diluting AlloP's effectiveness. Damn I sound like AlloP salesman now
